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Abstract

ANTICONVULSANT ACTIVITY OF AQUEOUS EXTRACT OF TRIDAX PROCUMBENS LINN LEAVES AGAINST MES INDUCED CONVULSIONS

More Raviraj Ramrao*, Burande M. D., Jangme C. M. and Shivakumar S. Ladde

ABSTRACT

The plant Tridax Procumbens L. belonging to the family Asteraceae is popularly known as Coatbuttons – Mexican Daisy in English, Gavpattha in Hindi, and Dagdipala in Marathi. The chemical constituents present are alkaloids, carotenoids, flavonoids (catechins and flavones), saponins and tannins. Mineral composition present in leaves is calcium, magnesium, potassium, sodium, and selenium. Leaf mainly contains crude proteins 26%, crude fiber 17% soluble carbohydrates 39% calcium oxide 5%, Luteolin, glucoluteolin, quercetin, and isoquercetin. Whereas the oleanolic acid, fumeric acid, β-sitosterol, and tannin is present in good amounts. In recent years, the medicinal properties of plants have been investigated in the light of scientific developments throughout the world, due to their potent pharmacological activities, low toxicity, and economic viability15. Hence, the present study was designed to verify the anticonvulsant effect of aqueous extract of Tridax Procumbens L. in experimental animals. The aqueous extract of Tridax procumbens Linn was extracted by Percolation method. Phenytoin 25 mg/kg body weight used as the standard drug and different dose of aqueous extract of Tridax Procumbens L. are used to evaluate its anticonvulsant activity on MES induced convulsion model. In the present study Phenytoin significantly (p<0.001) inhibited the convulsions (i.e. flexion, extension, clonus, stupor) due to maximal electroshock. Tridax procumbens 4.2, 8.4 and 12.6 mg/kg (i.p.) fail to inhibit the extension and the time to recover from MES. Thus the observations emanated in the present study indicated that the Tridax procumbens was not effective against MES. Lack of activity against MES induced seizures suggest that Tridax procumbens is not useful in suppressing generalized tonic-clonic seizures.

Keywords: Anticonvulsant effect, Tridax Procumbens Linn, MES induced convulsion, Phenytoin.


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