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Abstract

A PROSPECTIVE OBSERVATIONAL STUDY ON THE ANALYSIS OF UTILISATION PATTERN, SAFETY AND EFFECTIVENESS OF TENELIGLIPTIN IN TYPE 2 DIABETIC PATIENTS WITH CARDIOVASCULAR DISEASE

Prof. Dr. Mathew George*, Prof. Dr. Lincy Joseph, Dr. Venu Venkatappan, Gayathri H. S., Joan John and Sanjana Augusthy

ABSTRACT

Diabetes mellitus is a group of metabolic disorders characterised by hyperglycaemia and abnormalities in carbohydrate, fat and protein metabolism. It may result in chronic microvascular and macrovascular complications. The objectives of the study were to determine the utilization pattern, safety and effectiveness of Teneligliptin in type 2 diabetic patients with cardiovascular disease. This Prospective observational study was carried out at the cardiology department of a tertiary care teaching hospital for a period of six months. Patients were recruited as per the inclusion criteria. Predesigned structured proforma was used to collect information from the prescribing physicians regarding the effectiveness of Teneligliptin in T2DM patients. Information on the glycemic parameters at baseline prior to starting Teneligliptin and at the end of 3 months therapy was collected. The effectiveness was assessed by analyzing the mean change in 3-month values of HbA1c, FBS and PPBS. The eGFR can be calculated using MDRD equation. QTc interval prolongation checked through evaluation of ECG. The medication adherence was estimated using the MORISKY MEDICATION ADHERENCE SCALE - 8. Safety was assessed using NARANJO‘S CAUSALITY SCALE. This study shows that Teneligliptin provided statistically significant and clinically meaningful reductions in the HbA1c, FBS and PPBS in cardiac patients with T2DM.

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