Abstract

IN SILICO STUDIES ON DENGUE AND MARBURG VIRAL PROTEINS WITH SELECTED MURRAYA KOENIGII LEAVES CONSTITUENTS

Rameen Taj S., Sheetal V. Rao, Tulasi D. P., Nisha R., Pavithra K. and *Balasubramanian Sathyamurthy

ABSTRACT

Dengue and Marburg virus contains seven and six proteins respectively, which are considered to be the most effective for drug designing. Recent studies have shown that these proteins can effectively cause the inactivation of dengue and Marburg disease in humans. Phytochemicals present in Murraya koenigii can be used to prevent premature graying of hair and kidney pain. It has got antibacterial activity, anti fungal activity, anti protozoal activity. In this particular study, the binding efficiency of 5 compounds present in the Murraya koenigii with all the thirteen viral proteins was performed through in silico methods. By our molecular docking result, we found that the 2-Phenyl-4 Quinolinecarboxamide have highest binding affinity with the proteins and we also predicted the binding site amino acid residues and the type of hydrogen bonding.

Keywords: Murraya koenigii, molecular docking, binding affinities, 2-Phenyl-4 Quinolinecarboxamide.