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Abirame S.*


This study was a comparative in vivo study, conducted in Wistar albino rats at Trincomalee Campus, Eastern University of Sri Lanka. Thrombosis is the formation of a blood clot inside a blood vessel, obstructing the flow of blood through the circulatory system. When a blood vessel is injured, the body uses platelets (thrombocytes) and fibrin to form a blood clot to prevent blood loss. Thrombosis is a common pathology underlying ischemic heart disease, ischemic stroke and VTE. Major burden of disease across low-income, middle-income and high-income countries. Adult female Wister albino rats of weighing around 200-250gm were obtained. The animals housed in cages under standard laboratory condition. The Wister albino rats were divided into 2 groups 6 animals in each. Mean values of baseline bleeding time 84.50 ± 14.761sec in standard group and 88.50 ± 9.813 sec in test group after overnight fasting for 12 hours. After induced by intraperitoneal injection of the thromboplastin (#0203) - 0.48ml injection the mean values of bleeding time were subsequently decreased 69.50 ± 12.787 sec in standard group and 76.33± 9.688 sec in test group. Then the treatment was continued. Standard group administered with Phytomenadione (Vitamin K) and test group administered with test drug. After that rat’s tail bleeding time was noted at 0 min, 30min and 60min after 3h and 24h. Study was tested for (using assessment (Time-Dependence Pattern)) anti-thrombotic activity. Mean value results in Standard group (0 min: 76.50 ± 10.083s, 30 min: 74.20 ± 9.757s and 60 min: 75.80 ± 8.786s) after 3h. Mean value results in Standard group (0 min: 77.00 ± 8.485s, 30 min: 81.80 ± 7.396s and 60 min: 89.33± 6.377s) after 24h. In comparison of bleeding time, both the standard and test groups indicate significance of bleeding time (P value less than 0.05). Phytomenadione (Vitamin K) possess source of antithrombotic activity compounds for the management of various thrombogenic disorders.

Keywords: Antithrombotic activity, Phytomenadione (Vitamin K), Thrombosis, Thromboplastin, Bleeding time.

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