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Abstract

FORMULATION AND OPTIMIZATION OF FAST DISSOLVING TABLETS OF OLMESARTAN

*Jainabi S. K., Urmila R., Asha S., Bhavani Prasad V. and Rammurthi M.

ABSTRACT

The objective of the present study was to prepare fast disintegrating tablets of olmesartan with sufficient mechanical integrity to achieve faster disintegration for patient convenience. The tablets were prepared by direct compression method using superdisintegrants using sodium starch glycolate, cross carmellose sodium and cross povidone at 1, 1.2% level for F1 to F6 formulations and sodium bicarbonate at 1.8, 2, 2.2% levels, and citric acid at 0.2, 0.3%, 0.5% level. The tablets were evaluated for hardness, friability, disintegration, uniformity of drug content and dispersible time. They were found to be within I.P. limits. The drug content of all tablets were found to be 98.3 – 100.2%. FT-IR shows no interaction between drug and polymer. It was concluded that, the formulation F6 was found to be optimizing formulation having disintegration time 29 seconds and % of drug release 98.58% at the end of 10 min.

Keywords: Olmesartan, Super disintegrate, Fast Dissolving, Cross Carmellose.


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