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Abstract

FORMULATION AND EVALUATION OF SITAGLIPTIN ORAL DISINTEGRATION TABLETS USING SYNTHETIC SUPERDISINTEGRANTS

Dr. Naga Subrahmanyam S.*, Dr. G. V. Pavan Kumar and Dr. G. V. Naga Raju

ABSTRACT

Research work is formulate the oral disintegrate tablets of Sitagliptin by using Synthetic Superdisintegrants. To formulate oral disintegrating tablets of Sitagliptin using different ratios of synthetic super disintegrates by direct compression technique. The aim of the present study was to develop and optimize oral disintegrating tablets of drug (Sitagliptin) using synthetic superdisintegrants to give quick onset of action by rapidly disintegrating in a few seconds without the need of water with better patient compliance. In such cases, bioavailability of drug is significantly greater and adverse event is reduced than those observed from conventional tablet dosage form. By performing compatibility studies by IR spectrophotometry, no interaction was confirmed. The first 9 formulations of Sitagliptin were formulated with different Concentrations (3, 6, 8%) of Three super disintegrants namely, croscarmellose sodium, sodium starch glycollate and crospovidone. Microcrystaline cellulose was used as directly compressible vehicle. Aerosil used as glidant to improve the flow property of the formulation. Magnesium stearate is used as lubricant respectively. The FG1, FG2 formulations are formulated using fenugreek seed mucilage as a natural superdisintegrant in different concentrations (3 & 6%). The overall results indicated that formulation with croscarmallose sodium (8%) i.e. CCS3 formulation had a higher edge compared to other formulations containing superdisintegrants.

Keywords: Microcrystaline cellulose, oral disintegrating tablets, World Health Organization.


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