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Abstract

IN-VITRO FREE RADICAL SCAVENGING POTENTIAL OF TRADITIONAL SIDDHA FORMULATION SERAANKOTTAI NEI BY DPPH, NO, ABTS AND HYDROGEN PEROXIDE RADICAL SCAVENGING ASSAY

J. Nisha*, N. J. Muthu Kumar, S. Visweswaran, N. Anbu and V. Banumathi

ABSTRACT

Free radical and reactive oxygen species (ROS) becomes the main cause of several diseases in humans that are generated due to imbalance between formation and neutralization of prooxidants resulting in oxidative stress. They cause oxidative damage to lipids, proteins, and DNA, eventually leading to many chronic diseases, such as cancer, diabetes, aging, and other degenerative diseases in humans along with lipid peroxidation. Oxidative stress due to the production of free radicals such as superoxide radical (O2•−), hydroxyl radical (•OH), peroxide radical (ROO•), and nitric oxide radical, is the major cause of a variety of pathological conditions including coronary heart diseases, reperfusion injury, inflammation, drug toxicity and neurodegenerative diseases. There is a profound risk of using synthetic antioxidants which are known to have side effects and have been proved carcinogenic. Thus there has been increased interest in natural antioxidants, especially those of herbal and traditional origin. It has been reported that herbal formulations, their derivatives and analogs, represent over 50% of all drugs in clinical use, in which natural products derived from higher plants represent about 25% of the total. Antioxidant substances can scavenge the harmful action of the free radicals. Several siddha formulations which are reported to possess extensive antioxidant property one among such formulation is Seraankottai Nei (SKN). The results of DPPH radical scavenging assay has shown that the percentage inhibition of DPPH radical by test drug SKN ranges from 9.08 to 52.87%. Similarly the NO radical scavenging activity of the SKN ranges from 44.74 to 90.64%. ABTS radical scavenging activity of SKN was found to be 10.5 to 68.9% and with hydrogen peroxide radical scavenging activity it was from 5.85 to 54.96%. Based on the results obtained from the In-vitro anti-oxidant assay of the drug SKN it was concluded that the siddha formulation SKN has promising anti-oxidant activity and may be used for management of stress related disorders further detailed preclinical investigation has to be carried out to ensure the in-vitro data’s before prescribing the same for clinical application.

Keywords: Free radical, ROS, DPPH, ABTS, NO, Hydrogen peroxide, Siddha, Seraankottai Nei.


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