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Abstract

FORMULATION AND IN VITRO EVALUATION OF BUCCAL TABLETS OF FLUVASTATIN BY DIRECT COMPRESSION METHOD

S. Asha*, R. Urmila, Sk. Jainabi, M. Ram Murthi, Bangaruthalli J. and L. Ramanamma

ABSTRACT

Buccal drug delivery has been considered as an alternative to oral dosing for compounds subjected to degradation in the gastrointestinal tract or to hepatic first pass metabolism. An attempt has been made to develop buccoadhesive tablets comprising of drug containing bio adhesive layer and drug free backing layer to release the drug for extended period of time with reduction in dosing frequency. Various formulations of Fluvastatin buccal tablets were prepared by direct compression method using bio adhesive polymers like Carbopol 976 P, Xanthum gum and Chitosan. Buccal drug delivery system prolong the residence time of dosage form at the site and thus contribute to improved and/or better therapeutic performance of the drug. The maximum bio adhesive strength was observed in tablets formulated with Carbopol 976 P.

Keywords: Buccal, Fluvastatin, Carbopol 976 P, Xanthan gum, Chitosan.


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