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Abstract

K+ATP CHANNELS MODULATE HAEMODYNAMICS, BIOCHEMICAL AND HEMATOLOGICAL AFTER PRETREATMENT WITH THE K (ATP) OPENER PINACIDIL AND PHOSPHOLIPASE C INHIBITOR ON ETOMIDATE IN THE MICE

Subramaniam Kannan*, Manoj G. Tyagi and Jayaprakash Somasundaram

ABSTRACT

Etomidate intravenous anesthetics that are recognized to have minimal
effects on clinically measured endpoints of cardiovascular function.
Thus, they are often used as induction agents in patients with
hemodynamic instability. K+ATP channels are known to be activated
by hyperpolarizing agonists, such as diazoxide, pinacidil, cromakalim,
K+ATP channel agonists are used as therapeutic agents in a variety of
cardiovascular diseases, including essential hypertension, angina
pectoris, myocardial ischemia, and cerebral vascular disease. This
study was conducted to evaluate the effects of the potassium channel
opener drug Pinacidil and Phospholipase C inhibitor, U73122 on
Etomidate with K+ATP channels opener drug modified the effects on blood pressure, heart
rate and hematological parameters like the RBC, WBC, hemoglobin and serum alanine and
aspartate amino-transferase enzymes in the mice.

Keywords: ATP-sensitive potassium channel, Etomidate, Phospholipase C inhibitor, hemodynamic.


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