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Abstract

THE MEDICINAL EFFECTS OF GARCINIA KOLA STEM BARK EXTRACT ON RENAL TISSUES IN ALLOXAN INDUCED DIABETIC RATS (AIDRS)

Josiah S. Hart and John Nwolim Paul*

ABSTRACT

Background: The search for alternative means of managing illness or disease conditions is as old as man. Plant and its parts (e.g. seeds, stems, leaves, roots and bark, etc.) have continuously been explored as food and medicine. The prevalence of some of these diseases is becoming alarmingly high so much that it is becoming a world problem and indeed a public health concern. It has become expedient that drastic measures be taken to curb the outrageous growth of these medical conditions. Some of these medical conditions are a result of what we eat as food especially diabetes mellitus. Aim: The study was aimed at investigating the effects of Garcinia kola stem bark (GKSB) extract on the histology of the kidney in Alloxan induced diabetic rats (AIDRs). Significance of the Study: The result of this study will be very relevant in proffering alternative therapies in the management of diabetes. Materials and Methods: 72 male wistar rats grouped into six comprising 12 animals per group. Each group is further split into 4 weekly subgroups consisting of 3 animals per group. The six major groups were the Normal Control Animals, non diabetic animals, which did not receive any treatment of the extract. The 2nd was diabetic, and not treated throughout the experimental period. The 3rd was non diabetic but administered the plant extract at 35.8mg/kg b. w. dose. Results and Discussion: The study revealed that at the first week of inducing diabetes using Alloxan, the kidney tissues showed an obliterated Bowman’s capsular space. This response is considered a generalized tubulonephropathies ranging from tubulonephritis to edematous swellings. The study indicated that at the third week of the administration of Garcinia Kola stem bark extract; the damages on the renal tissues were amended showing intact glomeruli and renal tubules. This suggests that the Garcinia Kola stem bark extract had curative effect on the kidney. Conclusion: The study has shown that Garcinia Kola stem bark extract has medicinal effect on diabetic renal tissues. This further means that the extract has active ingredients that could be useful in the management of diabetic conditions.

Keywords: Kidney, Garcinia, Kola, Stem, Alloxan.


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