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Abstract

TESTING OF AMOXICILLIN LEVELS IN RESISTANCE CASES IN AN EFFORT TO MONITOR ANTIBIOTIC DRUG QUALITY AT THE TASIKMALAYA CITY HEALTH CENTER, INDONESIA

Danni Ramdhani*, Wiwiek Indriyati and Muhammad Aiman

ABSTRACT

Objective: Acute respiratory infection (ARIs) is an acute inflammation of the upper and lower respiratory tract caused by microorganisms, bacteria, viruses, and infectious rickets. Evaluation of the quality of antibiotics is done to determine the effectiveness of the desired therapy. This study aims to determine the levels of amoxicillin antibiotics used in ARIs treatment. Methods: Drug samples were obtained from health centers in the City of Tasikmalaya. Testing the levels of amoxicillin antibiotics was carried out using HPLC instruments, using validation parameters linearity, precision, accuracy, limit of detection (LOD) and limit of quantification (LOQ). Results: The test results showed that the levels of levofloxacin antibiotics that are used to meet the requirements that exist in the United State Pharmacopeia grading 104.95%, and the validation parameters that meet the requirements, correlation coefficient of 0.9993, recovery percent of 100.1%, precision 0.055%, LOD 0.082 μg/mL and LOQ 0.251 μg/mL. Conclusions: The test results showed that the levels of amoxicillin antibiotics that are used to meet the requirements that exist in the United State Pharmacopeia (USP).

Keywords: Acute respiratory infections, amoxicillin, resistance of antibiotics, validation parameters.


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