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Abstract

A REVIEW ON MEDICATED LOZENGES

Chandrawanshi Mayuri J., Sakhare R. S., Dr. Nagoba Shivappa N.* and
Bhalekar Rohini V.

ABSTRACT

Lozenges are palatable solid unit dosage form administer in oral cavity. These are the flavoured medicated dosage forms proposed to be sucked and held in the mouth or pharynx containing one or more medicament usually in sweetened base. Lozenges show local effect at a particular site in oral cavity. A lozenge also shows systemic effect for which the drug undergoes circulation in bloodstream and exhibits its pharmacological action. Types of lozenges are compressed tablet lozenges, hard candy lozenges, chewy or caramel based lozenges, soft lozenges, center filled hard lozenges etc. These lozenges are formulated by using different ingredients like candy base, binders, lubricants, flavouring, colouring, whipping agent and humectants. Lozenges are evaluated by hardness, friability, diameter and thickness, weight variation, moisture content, drug content/ assay, etc. Drug – Excipients interaction are studied by FTIR. In- vivo study, In vitro study. Lozenges provide easy administration, convenience to patient, patient compliance, and efficient treatment of low drug dosing, immediate onset of action, reduced dosage regimen, and cost effectiveness.

Keywords: Lozenges, local and systemic drug delivery, Excipients, prolonged release.


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