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Abstract

QUINAZOLINE A SCAFFOLD WITH ANTIMICROBIAL AND ANTICONVULSANT ACTIVITY: OVERVIEW

*Priyanka K. Patil and A. S. Jagdale

ABSTRACT

Pharmacologicaly active benzofused moieties mostly possess heterocyclic ring structures and presence of heteroatoms or groupings evinces privileged specificities in their pharmacological targets. Among the heterocyclic compounds, quinazolines has emerged as cardinal construction motif, which plays pivotal role in drug development. Quinazoline scaffold is known to possess some prime pharmacological activities like anti-mycobacterial, anti-microbial, antiviral, anti-oxidant, anti-inflammatory, anti-hypertensive, anticonvulsant etc. This broad spectrum of biological and biochemical activities has been further assisted by the synthetic flexibility of quinazoline, which permits development of large number of structurally diverse derivatives. Therefore, it is necessary to compile the latest information along with earlier information to understand present status of quinazoline nucleus in drug discovery. In the present review, various derivatives of quinazoline possessing antimicrobial, anti-convulsant potential are brought into limelight and their activity has been elucidated in accordance with structure activity relationship studies.

Keywords: Heterocycles, Quinazoline, Antimicrobial, anti-colvulsant.


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