QUINAZOLINE A SCAFFOLD WITH ANTIMICROBIAL AND ANTICONVULSANT ACTIVITY: OVERVIEW
*Priyanka K. Patil and A. S. Jagdale
ABSTRACT
Pharmacologicaly active benzofused moieties mostly possess
heterocyclic ring structures and presence of heteroatoms or groupings
evinces privileged specificities in their pharmacological targets.
Among the heterocyclic compounds, quinazolines has emerged as
cardinal construction motif, which plays pivotal role in drug
development. Quinazoline scaffold is known to possess some prime
pharmacological activities like anti-mycobacterial, anti-microbial, antiviral,
anti-oxidant, anti-inflammatory, anti-hypertensive, anticonvulsant
etc. This broad spectrum of biological and biochemical
activities has been further assisted by the synthetic flexibility of
quinazoline, which permits development of large number of structurally diverse derivatives.
Therefore, it is necessary to compile the latest information along with earlier information to
understand present status of quinazoline nucleus in drug discovery. In the present review,
various derivatives of quinazoline possessing antimicrobial, anti-convulsant potential are
brought into limelight and their activity has been elucidated in accordance with structure
activity relationship studies.
Keywords: Heterocycles, Quinazoline, Antimicrobial, anti-colvulsant.
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