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Abstract

DIVERSE ACTIONS OF HYPOXIA-INDUCIBLE FACTOR 1 INHIBITORS IN CANCER

Sandhya Chipurupalli* and Elango Kannan

ABSTRACT

In human cancers, hypoxic mass developed upon the quick tumor expansion has been considered as a driving force of hypoxia inducible factor 1 (HIF-1) mediated cancer progression. Moreover, hypoxic microenvironment has been an impediment for the available conventional therapy causing resistance to chemotherapy as well as radiotherapy. This has led to the development of small molecules targeting hypoxic tumor microenvironment, specifically to inhibit HIF- 1 mediated signaling. In this review, we emphasize on different small molecules developed to target hypoxia signaling and their proposed mechanism of actions.

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