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Abstract

PHYTOCHEMICAL SCREENING AND ANTI-PSORIATIC EVALUATION OF CITRUS SINENSIS PEEL EXTRACTS ON MOUSE TAIL MODEL

B. Vijay Kumar*, G. N. S. S. Chandra Sekhar, Ch. Venkatesh, Y. Manikanta, J. Nagalakshmi and Nadendla Rama Rao

ABSTRACT

Objective: To assess anti-psoriatic activity of the ethanol and aqueous extract from the peels of citrus sinensis on mouse tail model. Methods: Mouse tail test using Perry scientific tail model was used for the evaluation of anti-psoriatic activity. Aqueous extract and ethanol extract of (100mg/kg) were tested in Swiss albino mice. Parameters studied in the mouse tail test were changes in epidermal thickness and percentage orthokeratotic values. Results: The extracts from the peels of citrus sinensis produced significant orthokeratosis (P<0.01) in the mouse tail test. In epidermal thickness, a significant reduction with respect to control was observed in groups treated with flucinolone acetonide and ethanolic extract. Conclusion: From the above data, the extracts of citrus sinensis showed significant orthokeratosis on mouse tail test. To our knowledge, this is the first report on the anti-psoriatic effect of peels of citrus sinensis.

Keywords: Citrus sinensis, flucinolone acetonide, orthokeratosis.


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