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Abstract

SPECTROCOPIC METHOD DEVELOPMENT AND VALIDATION OF VALSARTAN BY USING PH 6.4 BUFFER

Surwade Kunal S.*, Gawai Mamta N. and Raut Abhijit R.

ABSTRACT

Simple precise accurate UV Spectroscopic method has been developed and validated for estimation of valsartan in bulk and pharmaceutical dosage form. It is approved for the treatment of hypertension. It is an angiotensin II receptor antagonist. UV Spectroscopic method which is based on measurement of absorption of UV light, the spectra of valsartan in Phosphate buffer PH 6.4 showed maximum wavelength at 252 nm and calibration curve were plotted over the concentrations ranging from 2-20μg/ml of valsartan with correlation coefficient 0.998 validation was performed as per ICH Q2 (R1) guidelines for linearity, accuracy, precision and recovery. The limit of detection (LOD) and limit of quantification (LOQ) were found to be 0.1224 and 0.3785 respectively by simple UV Spectroscopy. The proposed method was validated.

Keywords: Valsartan, Phosphate buffer PH 6.4, spectrophotometry and validation.


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