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*Bhujbal Pooja Sharad, Shinde Vishakha Vikas, Tajane Arti Shantaram, Shitole Pratiksha Balasaheb, S. S. Kadam, M. V. Gadhave, S. L. Jadhav and D. D. Gaikwad


Quinazolin-4-(3H)-one is a heterocyclic compounds, and its derivatives are synthetically important molecule, thus used for the synthesis of a large variety of compounds. The compound was first prepared condensation products of anthranillic acid and amides by Niementowski quinazolinone synthesis, named after its discoverer Stefan Niementowski (1866-1925). The original work was published in 1895. The first quinazoline 2-cyano-3, 4-dihydro-4-oxoquinazoline by griess at 1869. From literature survey states that most of the methods used for the synthesis of quinazolinone compounds make use of anthranillic acid or one of their functional derivatives as the starting materials. Quinazolin-4- (3H)-one is synthesized when keto group is introduced in the pyrimidine ring of quinazoline. Quinazolinone and its derivatives possess a large class of biologically active compounds that exhibited broad spectrum of biological activities such as anti-HIV, anticancer, antifungal, antibacterial, anti mutagenic, anticoccidial, anticonvulsant, anti-inflammatory, antidepressant, anti malarial, antioxidant, anti leukemic, and antileishmanial activities and other activities. Literature review state that quinazolinone derivatives have attracted strong interest in organic and medicinal chemistry due to their potent biological and pharmacological activities. The present review provides a brief overview on the recent advances and future perspectives on pharmacological aspects of quinazolinone and its derivatives reported in the last decade.

Keywords: Quinazolin-4-(3H)-one, Anti Fungal activity, Anti-inflammatory & Antioxidant activity, Anti Malerial Activity, Anti cancer Activity, Maleria Drug Discovery.

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