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Abstract

CURCUMINOID DERIVATIVES AND ITS BIOLOGICAL ACTIVITIES

A.N.V. Sunitha*, Lakshmi Naganathan, B. Chaithanya, R. Bhagya Jyothi and J.V.C. Sharma

ABSTRACT

Natural sources for medicine has got its importance and a lot of intense scientific research is happening on various chemical constituents and activities of large number of them with proper SAR studies. The current article is a study on curcuminoids and its derivatives. The natural curcumin is obtained from the rhizomes of turmeric plant and can be synthesized chemically. The possible sites for structural modifications on curcumin, curcumin derivatives, strategies for curcumin analogues, analogues synthesized, typical examples of analogues, bridged analogues, exotic analogues, biological activities of curcumin and its derivatives that includes their antioxidant property, anti-inflammatory property, anti-cancer property, cardiovascular activity, wound healing, anti-fungal and toxicological properties are studied.

Keywords: Curcumin, dihydrocurcuminglucuronide, araldehydes, ß-diketone, antiinflammatory, amti cancer, anti oxidant, cardiovascular, wound healing.


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