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Abstract

NOSE TO BRAIN DRUG DELIVERY

Tayde M. A. and Chavan S. R.*

ABSTRACT

The present review focuses on nasal drug delivery system, in which drug deliver to brain via targeted nasal route. The nasal mucosa used for delivery and systemic administration of various drugs across the brain. In this system physiological barriers like blood-brain-barrier (BBB) and blood-cerebrospinal fluid barrier (BCSFB) are avoided. Isotonic solutions of drug are usually preferred for nasal administration to avoid permeability problem. Nasal surface modification technology can be used as an excellent approach for nasal formulations.

Keywords: Nasal drug delivery system, Mucosa, BBB, BCSFB, Isotonicity, Nasal surface modification.


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