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Abstract

DEVELOPMENT AND VALIDATION OF STABILITY INDICATING RP - HPLC METHOD FOR THE ESTIMATION OF LORNOXICAM IN TABLET DOSAGE FORM

Y. Naga Durga Rao*, G. Eswar, P. Sheela Rani, S. Asha, P. Sai Bhanu, D. Mahendra

ABSTRACT

A simple reverse phase liquid chromatographic method was developed and validated as per the ICH guidelines for the quantitative determination of Lornoxicam in pharmaceutical dosage forms. The method was simple, precise, specific and accurate. The mobile phase consists of methanol and water (60:40 v/v). The proposed RP-HPLC method utilizes a 3.5μm Symmetry C18 column (150 mm ×4.6 mm) make YMC at ambient temperature. The eluent was monitored at 379 nm and retention time of Lornoxicam was 8 min. The linearity was observed from 10-60μg/ml with r2= 0.9984. The limit of detection and limit of quantitation were found to be 0.01μg/ml and 0.05μg/ml respectively. From the results obtained, it was worthwhile that the provided methods were robust for small and deliberate changes in experimental conditions.

Keywords: Lornoxicam, Anti-pyretic, RP-HPLC, Excipients, Validation.


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