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Abstract

DEVELOPMENT AND VALIDATION OF UV SPECTROPHOTOMETRIC METHOD FOR ESTIMATION OF COLCHICINE IN BULK AND PHARMACEUTICAL DOSAGE FORMS

Sravya A.*, Sahithi Purna A., Abdul Sadaf, Ravi Teja Reddy A., Sireesha D. and Vaudha Bakshi

ABSTRACT

The present study describes a method to analyze colchicine using UV spectrophotometry. Based on the spectrophotometric characteristics of colchicine, λmax selected was 246nm. The method was validated as per ICH guidelines and the parameters validated were linearity, range, accuracy, precision, LOD and LOQ. The method demonstrated linearity (r2 = 0.995) in the range of 2-20 μg/mL with linear equation y=0.006x+0.011. LOD and LOQ were found to be 1.81 and 5.47 μg/ml, respectively. The proposed method can be used for routine analysis of colchicine using water as solvent in bulk and tablet dosage forms.

Keywords: UV spectrophotometer, colchicine, ?max, ICH guidelines, Method development, Validation.


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