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Abstract

EVALUATION OF EFFECT OF MOISTURE ON NEOSTIGMINE METHYLSULFATE DRUG SUBSTANCE BY FTIR SPECTROSCOPY

Dr. Amit Gosar*, Kapil Bavane, Swati Patole, Shivaji Jadhav

ABSTRACT

The intermolecular carbon and hydrogen bonding interaction with that
of methylsulfate and counter ion of drug substance has been
investigated by FTIR Spectroscopy. This article mainly reports the
effect of moisture on Neostigmine methylsulfate drug substance by
FTIR Spectroscopy. The spectroscopic characteristics of O----H
complexes are specified. Neostigmine Methylsulfate is hygroscopic in
nature, the water molecule reacts with methylsulfate ion to form O----
H intramolecular hydrogen bonding, due to which IR spectra shows
noise and chemical shift at region of wavenumber about 3020 cm-1
and 2900 cm-1.

Keywords: Intramolecular hydrogen bonding, Hygroscopic, FTIR spectroscopy, Neostigmine Methyl sulfate


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