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Abstract

A CASE REPORT ON PREDNISOLONE INDUCED HYPERGLYCEMIA IN CHRONIC KIDNEY DISEASE AND ROLE OF CLINICAL PHARMACIST

Saikiran Velpula*, Nagaraju Vallepu, Bharathkumar Dasari, Laxmi prasanna Gummadi, Mahalaxmi Pykarao, Shyam Sunder Anchuri, Manishkumar Thimmaraju

ABSTRACT

Prednisolone is a 1, 2-dehydrocortisol which is highly potent synthetic
glucocorticosteroid which has minimal mineralocorticoid activity. Like
immunosuppressive or anti inflammatory agent Prednisolone can also
be used, which indicated in the treatment of various conditions,
including congenital adrenal hyperplasia, psoriatic arthritis, systemic
lupus erythematous, bullous dermatitis herpetiformis, seasonal or
perennial allergic rhinitis. Majorly it causes Cushing Syndrome, peptic
ulceration, edema, hypokalemia, muscle weakness, behavioral
changes. Hyperglycemia is the most common side effect of
Glucocorticoids and more representative. A 60 year old male patient
was consulted in the nephrology department with chief complaints of
shortness of breath, past medical history of patient includes hyperntension, diabetis mellitus,
chronic kidney disease, In-order to prevent serious adverse drug reactions of this drug, close
monitoring during treatment course, creating awareness, recognition of the problem and
careful management of all patients who receive this medication are essential.

Keywords: Prednisolone, hyperglycemia, adverse drug reaction.


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