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Abstract

ASSESSMENT ON EVALUATION OF SAFETY AND EFFICACY OF CEFOTAXIME AND CEFTRIAXONE IN LOWER RESPIRATORY TRACT INFECTIONS- A COMPARATIVE STUDY

Dr. Shushmaa Muchukota*, Noori Sulthana, Puja Basfore, Dr. Rinku Mathappan

ABSTRACT

Back ground: Lower respiratory tract infection (LRTI) is a broad terminology which includes bronchitis, pneumonia, acute exacerbations of chronic obstructive pulmonary disease, chronic bronchitis. World Health Organization (WHO) globally high burden of disease study estimated that (LRTIs) cases are around 429.2 million, episodes of illness and accounts for 94.5 million incapacity adjusted life years. In adults aged > 59 years, it causes 1.6million deaths. Betalactamase producing bacteria present a major problem in treating LRTIs. The objective of this study was to assess and evaluate safety, efficacy of ceftriaxone versus cefotaxime injection as an alternative therapeutic option for treatment of in patients (5-65 years) with LRTIs. Methods: This is a randomized and comparative study, performed for a period of six months a total of 110 inpatients with lower respiratory tract infections, from ESI hospital within the age range of 5- 65 years. Patients received ceftriaxone or cefotaxime injection intravenously during the treatment. Results: There was no difference between the two groups in demography or disease characteristics (p > 0.05) at baseline. Efficacy was evaluated in a total 110 patients. Both the treatment groups were comparable in response rate at the end of the therapy (p > 0.05). Clinical success rate was 94.8% and 88.5%, respectively for ceftriaxone and cefotaxime. Both the study medications were safe and well tolerated in the study population. Conclusion: In conclusion, ceftriaxone administered was found to be little more effective when compared with cefotaxime therapy. However, further studies with a large number of patients are required to confirm these findings with more robust microbiological evaluation.

Keywords: LRTI, Ceftriaxone, Cefotaxime, Randomized.


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