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Abstract

IN VITRO DISSOLUTION STUDIES OF SOME COMMERCIAL BRANDS OF ACECLOFENAC TABLETS

Harish K. H.*, Dinesh M., Jayanthi C. and Hanumanthachar Joshi

ABSTRACT

Aceclofenac has higher anti-inflammatory action than conventional NSAIDs. It is used for the relief of pain and inflammation in rheumatoid arthritis, osteoarthritis and ankylosing spondylitis with minimum side effects. Since Aceclofenac tablet is not an official product of I. P. and practically insoluble in water, it was thought to necessary to carryout in vitro testing of the commercial products with special attention to dissolution rate studies. The aim of the present study is to conduct the comparative dissolution studies to find out brand-to-brand variation by applying comparison approaches to the dissolution profile of marketed aceclofenac tablet formulations. Commercially available five different brands of aceclofenac tablets were randomly sampled from different medical shops. The study protocol was designed as per Indian Pharmacopeia. All the products met the requirements as per general specifications of Indian pharmacopoeia for tablet formulation.

Keywords: Aceclofenac, Indian Pharmacopeia, Dissolution, Commercial, Tablet formulation.


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