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Abstract

ASSESSMENT OF NEUROPHARMACOLOGICAL ACTIVITIES OF TAMARINDUS INDICA L. IN EXPERIMENTAL ANIMALS

G. B. Alaka Kar, Dr. Susanta Kumar Rout* and Debashisa Mishra

ABSTRACT

Tamarindus indica Linn is a plant that is used in traditional medicine for the treatment of cold, fever, stomach disorder, diarrhoea, jaundice and as skin cleanser. Tamarindus indica L. is a fruit tree (Magnoliophyta) is widely distributed in Asia. The available scientific information about Central nervous system (CNS) disorders of this species is scarce and there are no reports related to its possible effect on the CNS. The purpose of this study is to investigate the neuropharmacological activities like sedative effect (Phenobarbitone induced sleeping time, spontaneous motor activity, rotarod), anxiolytic effect (elevated plus-maze), antidepressant (forced swimming test), anticonvulsant (maximal electroshock and PTZ induced epilepsy) effects respectively, in laboratory animals by using hydroalcoholic leaf extract of Tamarindus indica L. The extract (250 mg and 500 mg) and standard drugs were administered orally. The extract at 500 mg/kg had an insignificant p>0.05 effect on shortened the onset time of sleep and prolonged the duration of sleep induced by phenobarbitone sodium. The extract also exhibited a significant (P<0.05) decrease of motor activity and exploratory behaviour in hole cross and open field tests. In the FST, the extract (250 and 500 mg/ kg) was as effective as fluoxetine (10 mg/kg) in reducing immobility, along with a significant increase in swimming and climbing, respectively. The extract (250-500 mg/kg), could not offered significant protection against MES and PTZ induced convulsion, but were found to delay significantly (p<0.05) the onset of tonic/clonic convulsion and also prolonged the time of death of the treated mice. These results suggest that some of the components of the hydroalcoholic extract of Tamarindus indica L. may have sedative, anxiolytic and antidepressant-like properties which deserve further investigation. In conclusion, the present work evidenced that sedative and anxiolytic effects of the extract might involve an action on benzodiazepine-type receptors, and also an antidepressant effect where noradrenergic and serotoninergic mechanisms will probably play a role.

Keywords: Sedative, anxiolytic, anticonvulsant activity, Central nervous system.


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