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Abstract

DEVELOPMENT AND EVALUATION OF LERCANIDIPINE FAST DISSOLVING TABLETS USING SOLID DISPERSION TECHNIQUE

Wagh Kalpesh S.*, Chaudhari Swapnil P. and Dr. Patil Prakash H.

ABSTRACT

The objective of the present study is to formulate the fast dissolving tablet of lercanidipine they are use the various Superdisintegrants over commonly used in Different Concentrations. The Super disintegrants are Crospovidone, Croscarmellose use, Sodium Starch glycolate. Lercanidipine is a dihydropyridines derivative. Lercanidipine is a calcium antagonist of the dihydropyridines group and selectively inhibits the transmembrane influx of calcium into cardiac and vascular smooth muscle, with a greater effect on vascular smooth muscle than on cardiac smooth muscle. Formulations containing Lercanidipine, Polxmer 188, Aerosil (300) solid dispersionsin 1:4:2 ratio prepared by Hot melt technique showed better Drug content dissolution rate. The disintegration time of optimized formulation F3 was found to 17±0.18 seconds. It was found that as the concentration of Superdisintegrants was increased, the time taken for wetting was reduced. The wetting time of F3 formulation was found to be 38±0.11 seconds. In-vitro disintegration of batch F3 gives rapid disintegration time and wetting time. Drug content was found to be 99.11% Results of in-vitro dissolution data shows that from formulation F1-F9 the batch F3 gives the drug release up to 98.03% in 25 min. Hence formulation F3 subjected for stability studies. Optimum formulation F3 is stable under stability conditions.

Keywords: Lercanidipine HCL, Fast Dissolving Tablet, In –vitro disintegration time.


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