WJPR Citation New

  All Since 2011
 Citation  2903  2393
 h-index  27  24
 i10-index  68  60

Login

Best Paper Awards

World Journal of Pharmaceutical Research (WJPR) will give best paper award in every issue in the form of money along with certificate to promote research activity of scholar.
            Best Paper Award :
Dr. Muhammad Baqir MR Fakhrildin
Download Article: Click Here

Search

Track Your Article

Abstract

A VALIDATED UV SPECTROSCOPIC ASSAY METHOD DEVELOPMENT FOR THE ESTIMATION OF DEFERIPRONE IN BULK AND ITS FORMULATION

A. Padma*, Dr. K. Thejomoorthy, A. Pallavi, B. Snehith and Mala Prashanth Kumar

ABSTRACT

The objective of work was to develop and validate a UV spectrophotometric method for deferiprone in bulk and its dosage form. The solvent and wavelength of detection were optimized in order to maximize sensitivity of proposed method. The method was validated for different parameters like linearity, precision, specificity, accuracy, limit of detection (LOD), limit of quantitation (LOQ) and robustness as per ICH guidelines (Q2). A wavelength maximum absorption of Deferiprone in 50% v/v ethanol was monitored at 278nm. The method was found to be linear in the range of 2 to 12μg/ml with a correlation coefficient (R2) of 0.999. The accuracy of the method was studied by recovery study and % recovery was found to be 101.07%. The LOD and LOQ were found to be 0.1808μg/ml and 0.547μg/ml respectively. The method is simple, accurate and requires relatively inexpensive instrument. The method was used successfully for determination of Deferiprone in bulk and its pharmaceutical dosage form.

Keywords: Deferiprone, Spectrophotometric method, ICH Guidelines, validation.


[Full Text Article]

Call for Paper

World Journal of Pharmaceutical Research (WJPR)
Read More

Email & SMS Alert

World Journal of Pharmaceutical Research (WJPR)
Read More

Article Statistics

World Journal of Pharmaceutical Research (WJPR)
Read More

Online Submission

World Journal of Pharmaceutical Research (WJPR)
Read More