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Abstract

EFFECTS OF SOME ANTIDIABETIC, ANTIHYPERTENSIVE, ANTIHYPERLIPIDEMIC AND ANTIPSYCHOTIC DRUGS ON INDIRECT BILIRUBIN LEVELS OF RABBITS (PART 1)

Sadia Ghousia Baig*, Qudsia Basri, Afshan Siddiq, Shadab Ahmed and Afaq Ahmed

ABSTRACT

This paper is a part of experimental studies done on chronic effects of different combination of drugs which are commonly used to treat hypertension, diabetes, hyperlipidemia and psychosis. In this study the effects of some commonly used drugs were observed on the serum level of unconjugated bilirubin. Male and female albino rabbits were divided into 9 groups of 7 animals in each. Treatments were given as: Group I (Distilled water 2 ml /kg), Group II (Risperidone 0.17 mg/kg), Group III (Olanzapine 0.17 mg/kg), Group IV (Metformin 22 mg/kg), Group V (Pioglitazone 0.5 mg/kg), Group VI (Losartan 0.7 mg/kg), Group VII (Candesartan 0.3 mg/kg), Group VIII Atorvastatin 0.35 mg/kg) and Group IX (Simvastatin 0.35 mg/kg). After 60 days of drug administration the serum indirect bilirubin level was determined. It was found that Simvastatin increased whereas Metformin decreased the level of indirect bilirubin significantly (P<0.05).

Keywords: Diabetes, Bilirubin, Metformin, Simvastatin, indirect bilirubin.


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