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Abstract

PROSPECTIVE STUDY ON EFFECT OF IMMUNOLOGICAL CONSEQUENCES AND THE MODULATION OF RESPIRATORY SYSTEM BY OCCUPATIONAL DISEASES

Y. Sri Harika, Sadaf Sultana, Qurratul Ayen Adeeba and B. Raja Narender*

ABSTRACT

The incidences of respiratory hypersensitivity and occupational respiratory diseases (ORDS) have been expeditiously increased over last decade. The term occupational respiratory diseases is a broad spectrum including various diseases such as occupational Rhinitis, Pneumoconiosis, Mesothelioma, Emphysema, Eosinophilia, Bronchitis, Asthma, Chronic obstructive pulmonary disease, lung cancer are the major consequences studied. This rise in the statistics of occupational respiratory diseases was tremendously increased equally in both adults and geriatric population. The present study on the immunological modulation in respiratory system caused mainly due to exposure to the organic dust toxic substances who have been admitted in tertiary care hospital considering sample size of 300 subjects. Age, sex, histopathological reports of the patients was considered at the time of visits. Specific settings and agents are quoted which have been indicated or confirmed as linked to occupational respiratory diseases in occupational works like coal miners, hard- rock miners, woodworkers, concrete manufacturing workers, painters, traffic police officers, industrial based workers, petrol bunk workers, cloth dyeing, flock workers, rice mill workers, textile industrial workers. The immunological consequences that are triggered by work place allergens, inflammatory mediators, gene immune responses and activation of cytokine pathways are triggered leading to pathological changes in these patients. During the analysis of the study it has been revealed that decrease in exposure to the organic dust toxic substance have subsidized the symptoms in the patient. The results revealed that different age group people belonging to distinct occupation having deteriorating health effects on respiratory system which is mostly due to organic dust exposure and preventive measures has to be considered during the professional working hours.

Keywords: Occupational Respiratory Diseases, Organic Dust Toxic Substances, Immunological Modulation, Cytokine Pathway.


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