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Abstract

LIPID PROFILE OF MALARIA INFESTED WISTAR ALBINO RATS TREATED WITH THE CRUDE EXTRACT OF ARTEMISIA ANNUA AND ARTEMISININ COMBINATION THERAPY

Ekam V. S.*, Ekam N. V., Ihe S. O. and Odio S. B.

ABSTRACT

The comparative effects of the crude extract of Artemisia annua and artemisinin combination therapy (ACT) on the lipid profile of wistar albino rats was evaluated in this study. Twenty four (24) rats used were divided into four (4) groups of six rats each. Group 1 (control) and 2 (malaria untreated) received 0.2ml of distilled water while group 3 (ACT treated) and 4 (A. annua treated) received 1.43mg/kg and 300mg/kg of ACT and A. annua extracts respectively. Treatment was administered twice a day for three consecutive days, after which blood sample was taken through cardiac puncture into treated sample bottles for analysis. The results showed that, TC, TG, HDL and LDL were significantly reduced (P<0.05) in both the malaria untreated and ACT treated groups when compared with the control while TC and LDL were significantly increased (P<0.05) in the A. annua treated group. The HDL and VLDL levels showed no significant change compared with the control. The results obtained from this study showed that, the TC levels for the experimental animals were within the normal physiological range except for the malaria untreated group which showed decreased levels, hence a lose in body weight. In this study, both ACT and the crude extract of Artemisia annua were compared, and it was discovered that both proved to be effective with no noticeable side effects, hence should be encouraged.

Keywords: Lipid, Artemisia annua, Plasmodium, artemisinin, phytochemicals, flavonoids, serum.


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