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Abstract

PHYTOCHEMICAL SCREENING & ANIMAL STUDY OF PANCH PHORON AQUEOUS EXTRACT ON MICE MODEL FOR EVALUATING ANTI-NOCICEPTIVE ACTIVITY

Md. Mominul Islam*, Tuly Deb, Rokeya Nazneen Jarna, S. M. Rayan Kabir, Sourabh Paul and Hasan Mahmud Reza

ABSTRACT

Background: The aim of this investigation to assess if the blend of spice contain bioactive molecules and determine the anti-nociceptive activity of Panch Phoron in mice model. Methods: Phytochemical screening by Wagner test, Fehling's test, Benedict's test, foam test, Libermann-Burchard's test, saponification test, lead acetate test, alkaline test, gum and mucilage test of panch phoron performed for the detection of phytochemicals. Inflammation was instigated by intraperitoneal injection of acetic acid to perform the writhing test for assessing the peripheral analgesic activity, and tail flick test was performed to measure the central analgesic activity. Results: In the results, panch phoron was found to have bioactive molecules: alkaloids, reducing sugar (ketones), saponins, phytosterols, fixed oils & fats, tannins, flavonoids, gum & mucilage. The analgesic effect of Panch phoron was as good as the standard Diclofenac sodium. Panch phoron (250 mg/kg; p.o.) demonstrated activity of 39.55% when used as aqueous extract while the standard drug Diclofenac Na had an event of 64.91% through the onset of action was slow. Conclusion: The presence of bioactive molecules in panch phoron ensures the presence of pharmacological activity. Tail flick and acetic acid-induced writhing test conclude, panch phoron to have both central and peripheral analgesic activity.

Keywords: Panch Phoron, phytochemical, nociceptive activity, aqueous extract.


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