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Abstract

HERBAL FLAVONOIDS IN TREATMENT OF HEPATIC DISEASES: A REVIEW

*Ammaarah Fatima Ahmed, Sobiya Fatima and Asif Rasheed

ABSTRACT

Liver is a vital organ of paramount importance which is the largest glandular organ in the body, located under the diaphragm in the upper right abdomen. In the anatomy and physiology the parts which make up liver are lobules, hepatic duct, portal vein and hepatic vein, inferior vena cava, other organs: Gallbladder and pancreas; Gastrointestinal blood flow and blood flow to the liver takes place. The liver performs many essential functions related to metabolism, immunity, and the storage of nutrients within the body; detoxification, protein synthesis and production of biochemical necessary for digestion and synthesis as well as break down of small and complex molecules. Hepatic diseases is a term for a collection of conditions, diseases, and infections that affect the cells, issues structures, or functions of the liver. Flavonoids are a class of plant and fungus secondary metabolites. Chemically, flavonoids have the general structure of a 15-carbon skeleton, which consists of two phenyl rings (A and B) and a heterocyclic ring (C). They are divided into seven classes: Anthocyanidins, proanthocyanidins, flavones, flavonols, flavan-3-ols, flavanones, isoflavones. Herbs which are rich in flavonoids are mentioned with their classes, dietary sources and uses. Example, rutin are found in green tea, grape seeds, citrus fruits etc and are used to treat cancer, osteoarthritis and heomorrhoids. Hepatic diseases, containing a wide range of hepatic pathologies from steatosis, hepatitis, and fibrosis to hepatocellular carcinoma (HCC), are leading causes of morbidity and mortality worldwide and have caused huge socioeconomic burdens. The main etiologies of hepatic diseases are cancer, NAFLD, hepatitis C, alcoholic liver disease, fibrosis. In this review, we aim to summarize and update the existing evidence of herbal flavonoids in the prevention and treatment of various hepatic diseases, while special attention is paid to the action mechanisms and were the signs & symptoms, pathophysiology and sources from which particular diseases are cured.

Keywords: Hepatic diseases, anthocyanidins, heomorrhoids, steatosis.


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