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Abstract

DEGRADATION STUDIES OF CEFUROXIME TABLET BY USING SPECTROPHOTOMETRIC TECHNIQUES

Nadeem Sheikh*, Dr. D. P. Kawade and Dr. D. R. Chaple

ABSTRACT

Forced degradation is a process whereby the natural degradation rate of a product is increased by the application of additional stress. A forced oxidative degradation study of Cefuroxime in tablet form was performed. The study was conducted based on available guidelines and main reference. Cefuroxime has a cepham ring in its structure. It can easily undergo hydrolytic, oxidative, thermal & photolytic degradation and the degraded products were analyzed by using UV spectrophotometry. The assay values of degraded products in different time intervals were analyzed by using UV spectrophotometry. Forced degradation was performed in tablet form using 0.1N Sodium hydroxide, 0.1N Hydrochloric acid, 30% Hydrogen peroxide solution respectively. Cefuroxime was subjected to hydrolytic, oxidative, photolytic and thermal degradation at different time intervals based on reference. The assay value of hydrolytic degradation of sample using 0.1N Sodium hydroxide was found to be 70.44% at the end of the 90 mins and 21.88% at the end of 1st day degradation. Complete degradation of Cefuroxime was observed at the end of 3rd day onwards. The assay value of hydrolytic degradation sample using 0.1N Hydrochloric acid was found to be 70.94% at the end of the 90 mins and 18.64% at the end of 1st day degradation. Complete degradation of Cefuroxime was observed at the end of 3rd day onwards. The assay value of oxidative degradation sample using 30% Hydrogen peroxide was found to be 67.90% at the end of the 90 mins and 59.12% at the end of 1st day degradation. Complete degradation of Cefuroxime was observed at the end of 3rd day onwards. In Thermal degradation only small amount of degradation was observed up to 5th day. It shows that sample exhibit stability against thermal degradation. At the end of the 5th day the assay value of sample was found to be 75.33% respectively. In Photolytic degradation also small amount of degradation was observed up to 5th day. It shows that sample exhibit stability against sunlight. At the end of the 5th day the assay value of sample was found to be 72.88% It was concluded that Cefuroxime was found unstable under hydrolytic and oxidative condition while is stable under thermal and photolytic degradation.

Keywords: Cefuroxime, Hydrolytic degradation, Oxidative degradation, Thermal and Photolytic degradation.


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