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Abstract

EVALUATION OF ANTIDEPRESSANT POTENTIAL OF ETHYL ACETATE PEEL EXTRACT OF GREEN AND YELLOW CITRUS LIMON

Nidhi Chauhan* and Dr. Jyoti Saxena

ABSTRACT

Objective: Citrus limon, a perennial tree of family Rutaceae is known for its pharmacological importance such as anti-microbial, anti-fungal, anti - carcinogenic, anti - neurodegenerative diseases (such as alzheimer’s, depression, etc.). The present study was designed to evaluate the role of the bioactive components of Citrus limon in treatment of neurodegenerative diseases. In this study, the antidepressant activity of ethyl acetate peel extract of yellow and green lemon was accessed in animal models. Method: Animal models were studied in mice. Forced swimming test (FST) and tail suspension test (TST) were used to determine the antidepressant effect of 200 and 400 mg/kg peel extracts by oral administration using imipramine (30 mg/kg) as standard drug. Result: The results revealed significant reduction in the immobility time of both the doses, 200 mg/kg and 400 mg/kg ethyl acetate peel extracts of yellow and green lemon. Antidepressant effect was found significant in comparison to vehicle or control (P<0.001), and showed similar results as that of standard imipramine drug. Conclusion: The results suggest that ethyl acetate peel extract of Citrus limon showed antidepressant like effect in mice, which can be attributed to its bioactivity. It may serve as an alternate therapeutic drug designing approach for depression, thus further investigations should be done to explore its pharmacological potential as an antidepressant.

Keywords: Citrus limon, Peel extract, Antidepressant activity, Forced swim test (FST), Tail suspension test (TST), Immobility time, Neuropharmacological significance.


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