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Abstract

LORAZEPAM EFFECT FOR PREVENTING POSTOPERATIVE NAUSEA AND VOMITING AFTER LAPAROSCOPIC CHOLECYSTECTOMY

Fatemeh Javaher Foroosh Zadeh*, Ali Ghomeshi and Motahareh Baba Zadeh

ABSTRACT

Background: Postoperative nausea and vomiting (PONV) are the most common symptoms affecting patients after surgery under general anesthesia and that is one of the most common causes of patient dissatisfaction after anesthesia. Objective: the purpose of this study was to evaluate the effect of oral lorazepam in reducing PONV after laparoscopic cholecystectomy. Methods: This doubles blind clinical prospective study was conducted on 76 patients aged 20-60 years, with American Society of Anesthesiologist physical status I or II who were scheduled for laparoscopic cholecystectomy, at Razi Hospital, Ahwaz, Iran from Desamber21, 2015 to January 20, 2016. Patients were divided in to lorazepam (Group 1) or control group (Group 2). Patients were assigned using a computer-generated random number table. The incidence of nausea and vomiting, use of antiemetic drugs and severity of nausea vomiting according to NVS score during the first 24 hours post anesthesia in 3 time periods (0, 6 and 24 hours post anesthesia). were recorded. Result: The comparisons of the groups for the number of patients with nausea showed a significant difference at 6(3.437times in group 2 more than group 1, p-value=0.003) and at 24 hours (4.391 times in group 2 more than group 1, p-value=0.007), also The comparisons of the groups for the number of patients with vomiting showed a significant difference at 0(3.954times in group 2 more than group 1, p-value=0.016) and at 6 hours (12.397 times in group 2 more than group 1, p-value<0.001), whereas there were no statistically significant differences at 24. Regarding to antiemetic uncovered a significant difference at recovery 10 patients in group 1 (26.3%)vs 12 patients in group 2(31.6%) hours (P <0.05) .The mean ± (SD) NVS score was 0.4 (0.2) in group 1 and 1.0 (0.2) in group 2 (P = 0.017) that is significant. Conclusion: We concluded that effectiveness of premedication with lorazepam for prevention of PONV after laparoscopic cholecystectomy. Trial registration: The trial was registered at the Iranian Registry of Clinical Trials (http://www.irct.ir) with the Irct ID: IRCT2014051917742N2. Funding: The authors received no financial support for the research, authorship and/or publication of this article.

Keywords: Post operative nausea and vomiting, Laparoscopic cholecystectomy, Lorazepam.


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