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Abstract

COMPARATIVE STUDIES ON THE EFFECT OF EXTRACTS OF Cymbopogon citratus (LEMON GRASS) ON THE LIPID PROFILES OF WISTAR ALBINO RATS

Adegbegi J. Ademuyiwa*, Usunobun Usunomena, Anyanwu, G. Olubunmi, Onoagbe O. Iyere

ABSTRACT

Plants of medicinal properties have been recognized to have therapeutic effects as well as toxic side effects. The present study aimed to investigate the effect of aqueous and ethanolic extracts of Cymbopogon citratus on the lipid profiles of normal rats. The lipid profiles of rats treated with both ethanolic and aqueous extracts of lemon grass as observed in table 3. The Total cholesterol, Triglycerides, High density lipoprotein (HDL) and low density lipoprotein (LDL) levels of the ethanolic extracts were observed to be significantly lowered when compared with the aqueous extract and the control normal rats. The results of the study also showed that the level of the LDL-Cholesterols in both ethanolic and aqueous extracts were decreased but not significantly (p<0.05) different when compared with the control group and the level of the HDL-Cholesterol in the treated groups. Thus, blood serum cholesterol level was found to be down regulated in this study. Findings in this study showed that this plant did not exert oxidative damage; in some instances, particularly in the liver, kidney and pancreas as well as its relative safety and possible use for weight gain.

Keywords: medicinal plants; lipid profiles; Cymbopogon citratus; rats; oxidative status.


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