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Abstract

ACUTE TOXICITY STUDY OF PROCESSED SIMPSHAPA IN WISTAR RATS –AN EXPERIMENTAL STUDY

Dr. Adivesh Arakeri*, Naik N. Sameer and Hiremath R.R.

ABSTRACT

Simpshapa is one amongst Salasaraadigana, Aasanadigana and
Mushkakadigana It is indicated in prameha & medoroga it effectively
does kapha & Medo dhatu shoshana The drugs used in the preparation
of Processed Simpshapa were, Simpshapa kanda sara, Simpshapa
kanda twak and Simpshapa patra. Only Simpshapa kandasara & kanda
twak are described in Prameha and Medo Roga in various Ayurvedic
classics. But there are many recent studies available on Anti- Diabetic
activity of Simpshapapatra. The description of the toxic signs or
complications on combination/ Processing of all three parts together
(Processed Simpshapa) are not available in classics and no any such
researches are documented till today. In present study, Simpshapa sara
is obtained by kastamarjana, to this Sara, bhavana is given with simpshapa kanda twak &
patra, later dried in shade. The processed shimpshapa Choorna is administered to female
wister rats and observed for 14 days. Results: No mortality, any toxic Signs were seen in the
dose of 5000mg/ kg body weight in any rats during the experimental study. None of the
animal showed any Signs of respiratory depression, Necrosis and catatonia and other toxic
signs during the experimental study. No signs of diarrhea, bloody stool, mucous in stool etc
were observed. Food consumption (10-12g/rat) and water intake (15-20ml/rat) was found
normal throughout the completion of the study. All the animals were found active throughout
the experimental study.

Keywords: Simpshapa, Acute toxicity study, Prameha, Medoroga, Kandasara.


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