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Abstract

SYNTHESIS AND EVALUATION OF SOME SUBSTITUTED BENZIMIDAZOLE DERIVATIVES FOR THEIR ANTIINFLAMMATORY ACTIVITY.

Honde Bharat S.*

ABSTRACT

A series of benzimidazole derivatives have been synthesized using substituted carboxylic acid and O-phenelyne diamine in presence of Protonic acid using magnetic stirrer. The synthesized compounds had been characterized using IR, 1H NMR and CHN analysis. The resulting compounds have been extensively studied for their anti-inflammatory activity using Carageenan induced rat paw edema method. Diclofenac is used as a standard drug. The entire synthesized compound possesses promising biological activity.

Keywords: Benzimidazole, anti-inflammatory activity, CHN analysis.


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