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Abstract

SPECTROPHOTOMETRIC METHOD FOR THE DETERMINATION OF NEPAFENAC IN OPTHALMIC FORMULATION

Deepak Wagh*, Dr. Sadhana R. Shahi, Priyanka D. Dabir and Swati Deore

ABSTRACT

The simple, accurate and precise UV-Spectrophotometric method has been developed and validated for quantitative determination of Nepafenac in opthalmic preparations. Two methods are proposed which employ Artificial Tear Fluid as a solvent. The drug is sparingly soluble in Artificial Tear Fluid but to avoid solvent cost and making method simpler the Artificial Tear Fluid as solvent was selected and the solubility of Nepafenac was enhanced by using SBE-beta- Cyclodextrin (Method B). Another reason for selecting ATF as a solvent was to determine the suitability of formulating Nepafenac in opthalmic preparation. The proposed methods obeyed the Beer’s law in the concentration range of 2-14 μg/ml. The linear regression showed good linear relationship with r2 =0.9990 and 0.9987, slope=0.07071 and 0.06485. Intercept were 0.16666 and -0.1237. Method was validated statistically where SD and RSD were found to be satisfactorily low. The results of the analysis were validated with respect to accuracy, precision and recovery studies which were found to be satisfactory. LOD for Nepafenac was found to be 1.524327003 and 0.504911475 μg/ml and LOQ was found to be 4.619172735 and 1.530034774 μg/ml respectively.

Keywords: Nepafenac, UV Spectrophotometry, Artificial Tear Fluid.


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