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Abstract

VALIDATED ABSORPTION CORRECTION METHOD FOR SIMULTANEOUS ESTIMATION OF ROSUVASTATIN CALCIUM AND EZETIMIBE IN TABLET DOSAGE FORM

*V. Raut and T.V. Walke

ABSTRACT

A new, simple, accurate and sensitive UV-Spectrophotometric absorption correction method has been developed and validated for simultaneous determination of Rosuvastatin calcium (RSV) and Ezetimibe (EZE) in a tablet dosage form. Methanol and distilled water (70:30) was used as a solvent. The wavelengths selected for analysis were 300 nm and 242.80 for Rosuvastatin calcium and Ezetimibe respectively. Beer’s law obeyed the concentration range of 10-35 mcg/ml for Rosuvastatin calcium and 5-30 mcg/ml for Ezetimibe. The percentage recovery was found in the range of 99.34% - 100.2% for Rosuvastatin calcium and 100.02% - 102.49% for Ezetimibe. The mean percentage drug content for Rosuvastatin calcium and Ezetimibe was found to be 103% and 108% respectively and % RSD value was found to be less than 2 which shows the precision of method. The developed method was validated statistically and by recovery studies. Thus the proposed method is simple, precise, economic, accurate and can be successfully applied for simultaneous determination of Rosuvastatin calcium and Ezetimibe in tablet dosage form.

Keywords: Rosuvastatin calcium, Ezetimibe, Absorption correction method, Spectrophotometer, Validated.


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