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Abstract

“EASTIMATION OF ANTI-LIPIDEMIC ACTIVITY OF BUTEA MONOSPERMA BY USING DEXAMETHASONE AS AN INDUCER IN WISTAR RATS’’

K. Salunkhe, V. Sonwane*, A Pakhare, R. Somani, S. Tembhurne and S. Kolhe

ABSTRACT

The present study was carried out to evaluate the antilipidemic activity of Butea monosperma aqueous flower extracts in dexamethasone induced diabetic rats for 15 days. Dexamethasone (10 mg/kg) was administered to male wistar albino rats to induce diabetes. These diabetic rats were grouped and treated with the aqueous flower extracts of Butea monosperma and glibenclamide separately for 15 days. Fasting blood glucose estimations and body weight measurements were carried out on 0th, 5th, 10th and 15th day of the experiment. On 15th day the serum was separated and analysed for biochemical parameter variations. The whole pancreas of rat were removed and subjected to histological examination. The Butea monosperma aqueous flower extracts at high dose (400mg/kg) and low dose (200mg/kg) exhibited significant (p<0.05 and p<0.01) anti-diabetic activity in dexamethasone induced diabetic rats. The extract also showed improvement in parameters like body weight and lipid profile as well as regeneration of β-cells of pancreas in diabetic rats.

Keywords: Butea monosperma, dexamethasone, fasting blood glucose.


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