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Abstract

DESIGN, DEVELOPMENT AND EVALUATION OF SUSTAINED RELEASE TABLETS OF METOPROLOL SUCCINATE USING EUDRAGIT POLYMERS.

William Arputha Sundar* and Dharani Purohit

ABSTRACT

The objective of the study was to develop sustained release tablets of Metoprolol Succinate (MS) using two different grades of EUDRAGIT polymers called Drugcoat RLPO and Drugcoat RSPO and to evaluate pharmacokinetic parameters of the optimized product. Sustained release tablets of Metoprolol Succinate were prepared using combination of different ratios of Drugcoat RLPO and Drugcoat RSPO. Study of pre compression and post compression parameters facilitated the screening of a formulation with best characteristics. The granules were prepared by wet granulation method using non-aqueous vehicles. The granules were coated with coating solution containing EUDRAGIT polymers. In-vitro drug release studies were performed using USP apparatus type II. It was found that 93% of the drug was released at the end of 20hrs. In-vitro release studies was conducted based on the data that all formulations follows zero order release kinetics and higuchi’s mechanism i.e. the drug was released by diffusion. Among all the 7 formulations F7 was found to be best matched formulation with respect to the marketed formulation.

Keywords: Sustained release, Metoprolol Succinate, DRUGCOAT RLPO, DRUGCOAT RSPO, ?-blockers.


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