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Abstract

QUALITY ANALYSIS OF DIFFERENT MARKETED BRANDS OF ATENOLOL (50 MG) TABLETS AVAILABLE IN SYRIA AND COMPARING WITH THE REFERENCE DRUG

*Mustafa Beesh, Mostafa Isbera, Karam Aboud and Ali Mohammad

ABSTRACT

There are numerous generics of atenolol tablets available in Syria. The purpose of current study is to assess the physicochemical characters of four brands(A, B, C, D) of atenolol(50mg) tablets advertised in Syria and comparing these properties with reference drug(E). The physicochemical equivalence of brands of atenolol tablets were evaluated through performing hardness, friability, weight variation, content uniformity, and dissolution rate tests. The highest values of hardness are founded in tablets brand A while other brands are nearest in hardness to reference drug. All tablets meet the specifications for friability, and weight variation tests. The content values for three brands (B, C, E) are included in the range (90-110%) according to USP specifications, while brands (A, D) failed the test. Brands (B, D, E) released more than 80% of drug in 30 minutes while brands (A, C) release less than 80%, so brands (B, D, E) passed USP specifications, While brands (A, C) failed this test.

Keywords: Atenolol, Hardness, Weight Variation, Content Uniformity, Dissolution Test.


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