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Abstract

INVESTIGATION OF WOUND HEALING ACTIVITY OF LINSEED OIL (LINUM USITATISSIMUM) IN ANTISEPTIC CREAM

Venkataramana Arbettu Padmanabha, Jayaganesh Sankar* and Jainendra Malakar

ABSTRACT

Wounds are unavoidable in the day to life and it causes by physical, chemical and biological attack and its cause the cell death /cell damage. Wounds make the disorder the tissue integrity and loss of cellular level biological activity of living tissues. Antiseptics are used as a treatment to cleanse cuts, scratches, burns, grazes or other minor injuries where the skin is broken, or as a preventive measure before piercing the skin. Linseed oil and its derivative are containing the higher amount of essential fatty acid, i.e. alpha linolenic acid. The alpha linolenic acid is essential for the biological synthesis of omega-3 fatty acid and it help to heal the wound. It having the higher amount of secoisolariciresinol diglucoside and it help to behave as a broad spectrum antimicrobial ingredients. Present study aims to develop the document of wound healing and microbial property of linseed oil containing antiseptic cream and the entire activity compared with the leading antiseptic benchmark samples. Results indicate that the antibacterial and antifungal activity of sample and benchmark sample found to be highly significant when compared to the control. Study results revealed that linseed oil accelerate the wound healing activity, wound healing activity of sample and standard found to be highly significant when compared to the control. In-house samples are having the slightly leading edge when compared to the benchmark samples. Incorporation of linseed oil in antiseptic cream is immense useful with respect to wound healing activity and microbial control.

Keywords: Antiseptic cream; linseed oil, boric acid, antimicrobial; wound healing, alpha linolenic acid.


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