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Vandana Ramesh* and K.V. Arun Kumar


The development of a novel drug delivery system for herbal drugs has a greater impact on today’s world population as it safe, effective, convenient and economically affordable. Liposomal formulations have successfully used in the treatment of various dermatological diseases. Both synthetic and herbal drugs are incorporated into liposomes to improve its efficacy. Symplocos racemosa, Rubia cordifolia and Azadirachta indica possess good anti-acne activity and their synergistic action when incorporated into liposomes have been studied. Liposomes were prepared by Lipid Film Hydration method and the drug extracts were incorporated into it. Liposomes were assessed for particle size determination and the mean particle size was found to be in between 2.77μm to 5.70 μm. The pH of the formulated gel was compatible with the pH of the skin. The viscosity, spreadability and swelling index studies also showed better results. This drug loaded liposomes are then added into carbopol solution and formulated into a liposomal gel. The formulated liposomes were characterized by SEM. The gel formulation F4 containing CH:SL-1:2 was found to be optimized. All the formulated gel were subjected for anti-bacterial studies and F4 showed comparatively better results. This formulated gel F4 was then compared with the standard Clindamycin gel. Stability studies indicated that the formulation was stable over a period of 3 months at the 25±2C and 2-8 ±3C. It was observed that the drug loaded liposome was more efficient against Propionibacterium acnes.

Keywords: Herbal drug, Liposomes, Acne vulgaris, Drug extracts, Propionibacterium acnes.

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