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Abstract

ANTI-INFLAMMATORY ACTIVITY OF ETHANOLIC EXTRACT OF LUFFA ACUTANGULA

Prajapati Palash*, Dwivedi Sangeeta, Vyas Narendra, Malviya Kirti, Malviya Sapna, Kharia Anil

ABSTRACT

The present study investigates the anti-inflammatory activity of ethanolic extract Luffa acutangula (fruit) using carrageenan induced paw edema in wistar albino rats. The medicinal values of the Luffa acutangula has been mentioned ancient literature as useful in the treatment of disorders of inflammation. Dried fruits of Luffa acutangula were powdered and extracted with ethanol using Soxhlation method. The anti-inflammatory activity was done by carrageenan induced hind paw edema method using Plethysmometer. Indomethacin used as a standard drug. For this activity Control group receive only carrageenan, Standard group receive indomethacin (40mg/kg), induced 0.1 ml carrageenan, test group receive ethanolic Fruit extract of Luffa acutangula (500mg/kg). The result showed that ethanolic extract of Luffa acutangula fruit exhibited statistically significant (p<0.05) inhibition of paw volume at a dose of 500 mg/kg. However, maximum inhibition of paw edema was found to be in Group II 91.70% and although the inhibition of paw edema with the extract was 72.73% which is less than standard group but higher than that of control group.

Keywords: Ethanolic fruit extract, Anti-inflammatory activity, excision wound, Plethysmometer.


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