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Abstract

ROLE OF GRANULOCYTE COLONY STIMULATING FACTOR IN IMPROVING ENDOMETRIAL THICKNESS IN INFERTILITY

Renuka Alsi* and Dr. Arpita Jaiswal

ABSTRACT

Despite of effective artificial reproductive techniques there is a plateau in rates of positive outcomes. So, now infertility clinicians and researchers have moved their focus towards endometrium and its ability to promote implantation.[1] Objective: We planned this study to demonstrated the use of granulocyte colony stimulating factor in patients undergoing IUI with thin endometrium (<7mm) on day of HCG trigger. Materials and Methods: This is a prospective study. 21 patients with thin endometrium on the trigger with endometrial thickness ≤7 mm received intra uterine instillation of G CSF (Neukin 300 mcg pre filled syringe) using IUI catheter. Endometrial thickness was reassessed after 48 hours. Results: endometrial thickness was improved in all the patients. Mean endometrial thickness pre infusion was 6.44±0.60 and post infusion was 8.22±1.12 (p value 0.0001, S). Difference in endometrial thickness was 2.22±1.12. There was no cycle cancellation. UPT was positive in 38.1% of patients. Conclusion: G CSF has the potential to improve endometrial thickness.

Keywords: Thin Endometrium, Granulocyte Colony Stimulating Factor, IUI.


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