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Abstract

EVALUATION OF ANALGESIC ACTIVITY OF METHANOLIC EXTRACT OF HOLARRHENA ANTIDYSENTERICA LEAVES BY TAIL IMMERSION AND HOT PLATE ASSAY METHODS

Ummey Jannatun Nahar, Mansura Akter, M. Mahbubur Rahman Bhuiyan and Mohammed Rahmatullah*

ABSTRACT

Objective: The alcoholic extracts of seeds and barks of Holarrhena antidysenterica have been reported to show antidysenteric, antibacterial, astringent, anthelmintic, stomachic and febrifugal properties. We aimed to evaluate analgesic potential of this plant using methanolic extract of leaf. Methods: In the present study, methanolic extract of Holarrhena antidysenterica leaves was obtained by maceration. Then, analgesic activity of the extract was investigated in mice at three different doses of 100, 200 & 300 mg/kg by using the conventional tail immersion and hot plate assays. Results: In the tail immersion assay, significant analgesia was shown by all doses at 30 & 60 min study period which was comparable to the reference standard (P<0.01). Similar to this, in hot plate assay basal latency times of response were significantly increased by all doses at 30 min study period. However, all doses showed gradual decrease in analgesia after 90 min in both tests. These results demonstrate possible indication of the medicinal use of the leaves of this plant along with mostly reported seeds and barks parts. Conclusion: The methanolic extract of leaves possess significant analgesic potential.

Keywords: Holarrhena antidysenterica; leaf extract; analgesic activity.


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