WJPR Citation New

  All Since 2011
 Citation  2903  2393
 h-index  27  24
 i10-index  68  60

Login

Best Paper Awards

World Journal of Pharmaceutical Research (WJPR) will give best paper award in every issue in the form of money along with certificate to promote research activity of scholar.
            Best Paper Award :
Dr. Muhammad Baqir MR Fakhrildin
Download Article: Click Here

Search

Track Your Article

Abstract

IN SILICO STUDY ON ANTINEOPLASTIC ACTIVITY OF MODIFIED PLANT BASED CHEMICAL INHIBITORS OF ANTI-APOPTOTIC PROTEINS

Dr. Mrityunjay Banerjee*, Sahin Mahboob and Dr. H. K. Sandeep Kumar

ABSTRACT

Cancer is one of the major disease currently affecting millions people worldwide and the number is growing rapidly ,Present study was aimed at finding a better alternative to natural chemical an anticancer chemotherapeutic drug Two target tubulin β-1 chain and apoptosis regulator Bcl-2 protein (2O2F) were used in the study of these structure of tubulin β-1chain is not known and that of Bcl-2 taken from protein data bank with ID 2O2F.Tertiary structure model of tubulin β-1 chain was predicted and validated .The validated 3D structure of tubulin β-1 chain and Bcl-2 protein was taken to study their interaction with 20 chemical structure mostly obtained from plant antineoplastic agents. Molecular docking of natural anticancer agents and its analougue was performed with these target separetly. The results indicate that Protein-ligand interactions were studied using Two target tubulin β-1 chain and apoptosis regulator Bcl-2 protein (2O2F), obtained from Protein data bank to evaluate the affinity of various Bcl-2 family proteins analogues towards ligand binding site and to study the extent of correlation between experimental values and computational dock scores, to proposed a new compounds with Raloxifen & Megestrol as the standard. The information generated from the present study should be useful in the design of more potent inhibitors of anti-apoptotic proteins as anticancer agents.

Keywords: Natural Anticancer agent, ADME, Bcl-2 protein, Docking.


[Full Text Article]

Call for Paper

World Journal of Pharmaceutical Research (WJPR)
Read More

Email & SMS Alert

World Journal of Pharmaceutical Research (WJPR)
Read More

Article Statistics

World Journal of Pharmaceutical Research (WJPR)
Read More

Online Submission

World Journal of Pharmaceutical Research (WJPR)
Read More